Dr.
Stourman is interested in and conducts research on bacterial functional
genomics during response to stress. She investigates bacterial
glutathione metabolism and the mechanism and the biological role of
bifunctional enzyme glutathionyl spermidine synthetase/amidase
(GSS) and its products in E.coli.
Recent
Publications:
Wadington MC, Ladner JE, Stourman NV, Harp JM, Armstrong RN. Analysis of the Structure and Function of YfcG from Escherichia coli Reveals an Efficient and Unique Disulfide Bond Reductase. Biochemistry. 2009 Jul 21;48(28):6559-61.
Functional Genomics in Escherichia coli: Experimental Approaches for the Assignment of Enzyme Function. Stourman, N. V., Wadington, M. C., Schaab, M. R., Atkinson, H. J., Babbitt, P. C. and Armstrong, R. N. Proceedings of "3rd International ESCEC Symposium on Experimental Standard Conditions on Enzyme Characterizations" Sept. 23rd - 26th, 2007, Ruedesheim, Germany, p.1-12.
Conformational
dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis
monitored by FRET. Lepesheva, G. I.; Seliskar, M.; Knutson, C. G.;
Stourman, N. V.; Rozman, D.; Waterman, M. R. Arch. Biochem. Biophys. 2007, 464(2), 221-227.
Silencing of
the Tropomyosin-1 gene by DNA methylation alters tumor suppressor
function of TGF-β Varga,
A. E.; Stourman, N. V.; Zheng, Q.; Safina, Al. F.; Quan, L.; Li, X.;
Sossey-Alaoui, K.; Bakin, A. V. Oncogene
2005, 24(32), 5043-5052.
Smad3-ATF3
signaling mediates TGF-β
suppression of genes encoding Phase II detoxifying proteins. Bakin, A.
V.; Stourman, N. V.; Sekhar, K. R.; Rinehart, C.; Yan, X.; Meredith, M.
J.; Arteaga, C. L.; Freeman, M. L. Free
Radic. Biol. Med. 2005,
38(3), 375-387.
Catalytic
Mechanism of Dichloromethane Dehalogenase from Methylophilus sp. Strain
DM11. Stourman, N. V.; Rose, J. H.; Vuilleumier, S.; Armstrong, R. N. Biochemistry 2003, 42(37), 11048-11056.
Key structural features of nonsteroidal ligands for binding and
activation of the androgen receptor. Yin, D.; He, Y.; Perera, M. A.;
Hong, S. S.; Marhefka, C.; Stourman, N.; Kirkovsky, L.; Miller, D. D.;
Dalton, J. T. Mol. Pharmacol.
2003, 63(1), 211-223.
Local Protein
Dynamics and Catalysis: Detection of Segmental Motion Associated with
Rate-Limiting Product Release by a Glutathione Transferase. Codreanu,
S. G.; Ladner, J. E.; Xiao, G.; Stourman, N. V.; Hachey, D. L.;
Gilliland, G. L.; Armstrong, R. N. Biochemistry
2002, 41(51), 15161-15172.
Novel nonsteroidal ligands with high binding affinity and potent
functional activity for the androgen receptor. He, Y.; Yin, D.; Perera,
M.; Kirkovsky, L.; Stourman, N.; Li, W.; Dalton, J. T.; Miller, D. D. Eur. J. Med. Chem. 2002, 37(8), 619-634.
Conjugation
of Haloalkanes by Bacterial and Mammalian Glutathione Transferases:
Mono- and Dihalomethanes. Wheeler, J. B.; Stourman, N. V.; Thier, R.;
Dommermuth, A.; Vuilleumier, S.; Rose, J. A.; Armstrong, R. N.;
Guengerich, F. P. Chem. Res. Toxicol.
2001, 14(8), 1118-1127.
Conjugation of Haloalkanes by Bacterial and Mammalian Glutathione
Transferases: Mono- and Vicinal Dihaloethanes. Wheeler, J. B.;
Stourman, N. V.; Armstrong, R. N.; Guengerich, F. P. Chem. Res. Toxicol. 2001, 14(8), 1107-1117.
