Professor Emeritus Molecular Biology and Microbiology Division Dept. of Biological Sciences Youngstown State University Youngstown, OH 44555-3601 Phone: (330) 742-1945 |
Research
Currently we have two ongoing research projects.
For the past 13 years we have been working with several local nursing facilities in an attempt to control chronic urinary tract infections in their patients. We were the first to demonstrate that enhancing the anti-adherence activity of a glycoprotein in the urine effectively controls these infections.
Since 1993 we have also been working with directed mutation. Using a lac- strain of Escherichia coli, we have been able to demonstrate an increase to lac+ revertants on basal medium containing lactose. This suggests that organisms may be able to respond to their environment in times of stress and direct the initiation of specific mutations that are advantageous to the organism.project examines the function of natural killer cells, white blood cells that help fight virus infection and cancer.
Publications
Sobota, A. E. 1993. A one-step method for capture of DNA from agarose gels. Biotechniques 14 (5):742.
Sobota, A. E. and L. L. Apicella. 1990. Reduction in the anti-adherence activity of Tamm-Horsfall protein with increasing concentrations of calcium. Urol. Res. 19:177
Sobota, A. E. 1984. Inhibition of bacterial adherence by cranberry juice: Potential use for the treatment of urinary tract infections. J. of Urology 131:1013-1016