Diana L. Fagan Associate Professor Molecular Biology and Microbiology Division Dept. of Biological Sciences Youngstown State University Youngstown, OH 44555-3601 Phone: (330) 941-1554 E-mail: dlfagan@cc.ysu.edu

• Ph.D. - University of Texas Southwestern Medical Center, Microbiology/Immunology, 1986
• B.S. - University of Texas Medical Branch at Galveston, Medical Technology (MTASCP) 1976

Semester System
• BIOL 1560: Microbiology for Health Professions
• BIOL 3703: Clinical Immunology
• BIOL 3718: Women, Science and Technology
• BIOL 6957: Advanced Immunology
• BIOL 5840: Advanced Microbiology
• BIOL 7010: Techniques in Tissue Culture

I and my graduate students perform experiments that examine the role of the immune system in health and disease. We are interested in two separate areas of investigation at this time. In our clinical project we study the development of Acute Respiratory Distress Syndrome in patients who have been admitted to the surgical intensive care unit as the result of a car accident or gunshot wound. This syndrome involves the inappropriate activation of the immune response, resulting in lung injury and possibly death of the patient. We are examining the patient's white blood cells for the presence of markers (cell adhesion molecules) that may indicate which patients will develop this syndrome. Our second project examines the function of natural killer cells, white blood cells that help fight virus infection and cancer.
 

Publications

Prehn, J. L., D. L. Fagan, J. A. Adams, S. C. Jordan. 1992. Regulation of tumor necrosis factor and CD-14 gene expression by 1, 25-dihydroxyvitamen D3. Blood 80:2811

Fagan, D. L., J. L. Prehn, S. C. Jordan, J. S. Adams. 1991. The human myelomono-cytic cell line U937 as a model for studying alterations in monokine gene expression by 1, 25-dihydroxyvitamen D3. Mol. Endocrinol. 5: 179.

Merlie, J. P., D. L. Fagan, J. Mudd, P. Needleman. 1988. Isolation and characterization of the cDNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J. Biol. Chem. 263: 3550

On the Web

Fagan, D., C. Willis, B. Mullins and J. Garr. 1998. Women in Science and Technology (Draft Syllabus). www.uwosh.edu/programs/wis/youngstown.htm