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Chemistry
4850 is a chance to get into a chemistry lab and have a go at
original
research. None of that "cook-book" stuff from chemistry classes, this
is science that has never been done before; a real opportunity to see
how a lab
works and to get involved with an ongoing research effort. It is
absolutely
invaluable experience if you want to go to graduate school in chemistry
and
will make you highly competitive if you want to enter the job market as
a BS
scientist. You will gain plenty of experience in many of the following:
- Reaction
setup including inert atmosphere work, analysis by TLC, reaction
workup, product isolation, and purification by techniques such as flash
column and crystallization
- Analysis
of products by 1H and 13C NMR by learning to
use the department's 400 MHz NMR
spectrometers, as well as by IR and MS techniques
- Molecular
modeling of compounds using packages such as PC Spartan and Alchemy
- X-Ray
crystallography on suitable samples using the department's diffractometers
under the guidance of Dr. Matt Zeller or Dr. Tim Wagner
Undergraduate
students are involved in various projects aimed at glycomimetic
synthesis and reaction development,
including
our attempts to produce new antibiotics against Staphylococcus
aureus. Over the summer of 2007 students discovered an interesting SN2
conversion (below) that was featured in a recent YSUpage story (link).
If you have taken Chemistry 3719/3720 and are interested in having a
go, drop
by 6014 Ward Beecher to see what we have to offer.
Recent
publications from
the Norris Group featuring undergraduate coauthors:
Crystal structure of
1-(2,3:5,6-di-O-isopropylidene-beta-D-mannofuranosyl)-1H-[1,2,3] triazol-4,5-
dicarboxylic acid diethyl ester, H.
Seibel, P.L. Miner, P. Norris, and T.R.
Wagner, J.
Chem. Cryst., 2007, 37, 157-163.
Application of
Bis(diphenylphosphino)ethane in Staudinger-type N-Glycosyl Amide Synthesis,
D.
P. Temelkoff, C. R. Smith, D. A. Kibler, S. McKee, S. Duncan, M. Zeller, M. Hunsen,
and P. Norris, Carbohydr.
Res. 2006, 341, 1645-1656.
Cu(I)-Catalyzed formation
of D-mannofuranosyl 1,4-disubstituted 1,2,3-triazole carbohybrids, P.L.
Miner, T.R.
Wagner, and P. Norris, Heterocycles 2005, 65, 1035-1049.
Rapid access to
glucopyranosyl-1,2,3-triazoles via Cu(I)-catalyzed reactions
in water, R.A. Akula, D.P.
Temelkoff, N.D.
Artis, and P.
Norris, Heterocycles 2004, 63, 2719-2725.
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